Kaplan Step 1 Question Of: The Day

One Tuesday, the question read: A 45-year-old man with a 30-pack-year smoking history presents with hemoptysis and weight loss. A chest CT shows a 4 cm central right hilar mass. Bronchoscopy with biopsy reveals small cells with scant cytoplasm, nuclear molding, and high mitotic rate. Which paraneoplastic syndrome is most likely to occur early and be detectable serologically before the cancer is visible on imaging? Samira thought: Small cell lung cancer → paraneoplastic → SIADH or Lambert-Eaton? She quickly chose (antibodies against presynaptic voltage-gated calcium channels).

The answer was . The correct answer was anti-Hu associated paraneoplastic encephalomyelitis/sensory neuronopathy . kaplan step 1 question of the day

Dr. Samira Mehta was three months into her Step 1 dedicated study period. Every morning at 6:00 AM, she opened the Kaplan Step 1 Question of the Day on her phone. Most days, she’d answer quickly, glance at the explanation, and move on. One Tuesday, the question read: A 45-year-old man

The resident raised an eyebrow. “Where’d you learn that?” Which paraneoplastic syndrome is most likely to occur

She sighed. Another esoteric fact I’ll never see again.